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Age (Dordr). 2012 Aug;34(4):895-904. doi: 10.1007/s11357-011-9286-5. Epub 2011 Jul 15.

Age-related changes of apolipoprotein D expression in female rat central nervous system with chronic estradiol treatment.

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  • 1Department of Morphology and Cellular Biology, 8ª Planta Facultad de Medicina, University of Oviedo, c/ Julián Clavería s/n, Oviedo, Spain.


Aging is associated with a reduction in metabolic functions, increased incidence of neurodegenerative diseases, and memory or cognitive dysfunction. With aging, a decrease in plasma estrogen levels, related to loss of gonadal function, occurs in females. Estrogens have neuroprotective effects and estradiol treatment improves some aspects of neuronal homeostasis affected by aging. In other way, recent studies show that apo D can play a neuroprotective role in some neuropathologies and during aging. The possible relation between estradiol treatment and the expression of apo D, during aging in the CNS, was investigated in female rats. Our results confirm an expression of apo D zone-dependent, in relation with aging, and an overexpression of apo D related to ovariectomy and estradiol treatment. This overexpression strengthens the idea that apo D plays a neuroprotective role in the CNS.

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