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Trends Endocrinol Metab. 2011 Oct;22(10):389-93. doi: 10.1016/j.tem.2011.06.001. Epub 2011 Jul 13.

The vaginal microbiome in health and disease.

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  • 1Institute for Genomic Biology, University of Illinois, Urbana, IL 61801, USA.

Abstract

Infections of the vaginal tract result from perturbations in the complex interactions between the microbiome and the host vaginal ecosystem. Recent data have linked specific vaginal microbes and urogenital infection with preterm birth. Here we discuss how next-generation sequencing-based approaches to study the vaginal microbiome will be important for defining what constitutes an imbalance of the microbiome and the associated host conditions that lead to subsequent infection and disease states. These studies will provide clinicians with reliable diagnostic tools and treatments for women who are at increased risk for vaginal infections, preterm birth, HIV and other sexually acquired diseases, and will provide opportunities for intervention.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21757370
[PubMed - indexed for MEDLINE]
PMCID:
PMC3183339
Free PMC Article
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