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Vaccine. 2011 Jul 22;29 Suppl 2:B56-62. doi: 10.1016/j.vaccine.2011.04.105.

Surveillance of illness associated with pandemic (H1N1) 2009 virus infection among adults using a global clinical site network approach: the INSIGHT FLU 002 and FLU 003 studies.

Collaborators (247)

Dwyer DE, Davey RT, Losso MH, Lynfield R, Cozzi-Lepri A, Gey D, Herman-Lamin K, Hoppe A, Lane HC, Lundgren JD, Neaton JD, Pett SL, Standridge B, Uyeki TM, Wentworth D, Munroe D, Rappoport C, Schwarze S, Aagaard B, Adzic D, Grarup J, Herrero P, Jansson P, Kjær J, Jakobsen ML, Jensen B, Jensen KB, Juncher H, Lopez P, Mocroft A, Pearson M, Portas B, Sabin C, Tillmann K, Babiker A, Braimah N, Collaco-Moraes Y, Hudson F, Kummeling I, Pacciarini F, Paton N, DuChene A, George M, Harrison M, Krum E, Larson G, Nelson R, Quan K, Quan SF, Reilly C, Schultz T, Thompson G, Wyman N, Avihingsanon A, Cassar L, Charoentonpuban K, Emery S, Laohajinda K, Jupimai T, Lanusse I, Moricz A, Otegui I, Ruxrungtham K, Robson R, Finley E, Gordin F, Sanchez A, Vjecha M, Baxter J, Brown S, Ghedin E, Halpin R, Hoover M, Baseler B, Metcalf JA, Cox N, Gubareva L, Hancock K, Katz J, Klimov A, Shaw M, Rubinson L, Barcan L, Alberto Corral J, Omar David D, Laplume HE, Beatriz Lasala M, Lopardo GD, Losso MH, Lupo S, Warley E, Bloch M, Dwyer DE, Moore R, Pett SL, Roth N, Soo TM, Vlahakis E, Burgmann H, Clumeck N, De Wit S, Florence E, Kabeya K, Weckx J, Perez C, Wolff MJ, Gerstoft J, Lundgren JD, Østergaard L, Zilmer K, Bogner JR, Brockmeyer NH, Faetkenheuer G, Klinker H, Plettenberg A, Rockstroh J, Stephan C, Antoniadou A, Koratzanis G, Koulouris N, Polixronopoulos V, Sambatakou H, Vasilopoulos N, Caplinskas S, La Rosa A, Mendo F, Salazar R, Valencia J, Bakowska E, Horban A, Knysz B, Antunes F, Doroana M, Padayatchi N, Dalmau D, Fernandez-Cruz E, Gatell JM, Sanz Sanz J, Soriano V, Chetchotisakd P, Ruxrungtham K, Suwanpimolkul G, Leen CL, Cohen C, Cohn DL, DeHovitz JA, El-Sadr W, Glesby M, Gordin FM, Hodder S, Markowitz N, Novak RM, Schooley R, Simon GL, Tedaldi EM, Temesgen Z, Timpone J, Uslan DZ, Heeter B, Barcan L, Alberto Corral J, Omar David D, Laplume HE, Beatriz Lasala M, Lopardo GD, Losso MH, Warley E, Dwyer DE, Elliott J, Konecny P, McBride J, Pett SL, Burgmann H, Clumeck N, De Wit S, Jorens P, Kabeya K, Wolff MJ, Chiu T, Wu, Gerstoft J, Mathiesen L, Nielsen H, Ostergaard L, Stenvang S, Pedersen, Bergmann F, Bogner JR, Brockmeyer NH, Faetkenheuer G, Klinker H, Rockstroh J, Stephan C, Antoniadou A, Koratzanis G, Koulouris N, Polixronopoulos V, Sambatakou H, Vasilopoulos N, Maagaard A, Mendo F, Salazar R, Bakowska E, Horban A, Padayatchi N, Dalmau D, Estrada V, Fernandez-Cruz E, Knobel H, Freud, Blazquez Garrido RM, Gatell JM, Sanz Moreno J, Pano-Pardo JR, Sanz Sanz J, Soriano V, Chetchotisakd P, Ruxrungtham K, Suwanpimolkul G, Angus BJ, Chadwick DR, Dockrell D, Leen CL, Newport M, Wilkins E, Anderson H 3rd, Baker JV, Cohn DL, DeHovitz JA, El-Sadr W, Freiberg MS, Gordin FM, Gulick R, Gurka D, Hodder S, Markowitz N, Novak RM, Paez A, Patil N, Reboli A, Sands M, Schooley R, Simon GL, Temesgen Z, Timpone J, Uslan DZ, Heeter Wade B.

Author information

  • 1Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital, PO Box 533, Wentworthville, NSW 2145, Australia. dominic.dwyer@sydney.edu.au

Abstract

The novel pandemic influenza A (H1H1) 2009 virus spread rapidly around the world in 2009. The paucity of prospective international epidemiologic data on predictors of clinical outcomes with pandemic (H1N1) 2009 virus infection stimulated the INSIGHT network, an international network of community and hospital-based investigators, to commence two worldwide clinical observational studies to describe pandemic (H1N1) 2009 virus activity. The purpose of these two studies was to estimate the percent of adult patients with illness due to laboratory-confirmed pandemic (H1N1) 2009 virus infection that experience clinically significant outcomes and to study factors related to these outcomes. Enrollment commenced in October 2009 and will continue until August 2011: as of the end of 2010, 62 sites in 14 countries in Australasia (12 sites), Europe (37) and North America (13) have enrolled 1365 adult patients, with 1049 enrollments into the FLU 002 outpatient study and 316 into the FLU 003 hospitalization study. These 'in progress' INSIGHT influenza observational studies may act as a model for obtaining epidemiological, clinical and laboratory information in future international disease outbreaks.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21757105
[PubMed - indexed for MEDLINE]
PMCID:
PMC3703507
Free PMC Article
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