Display Settings:

Format

Send to:

Choose Destination
Enzyme Res. 2011;2011:398751. doi: 10.4061/2011/398751. Epub 2011 Jul 2.

Determinants for Substrate Specificity of Protein Phosphatase 2A.

Author information

  • 1Department of Pharmacology, University of Iowa, 2-432 BSB, Iowa City, IA 52242, USA.

Abstract

Protein phosphatase 2A- (PP2A-) catalyzed dephosphorylation of target substrate proteins is widespread and critical for cellular function. PP2A is predominantly found as a heterotrimeric complex of a catalytic subunit (C), a scaffolding subunit (A), and one member of 4 families of regulatory subunits (B). Substrate specificity of the holoenzyme complex is determined by the subcellular locale the complex is confined to, selective incorporation of the B subunit, interactions with endogenous inhibitory proteins, and specific intermolecular interactions between PP2A and target substrates. Here, we discuss recent studies that have advanced our understanding of the molecular determinants for PP2A substrate specificity.

PMID:
21755039
[PubMed]
PMCID:
PMC3132988
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Write to the Help Desk