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Am J Physiol Regul Integr Comp Physiol. 2011 Oct;301(4):R1067-77. doi: 10.1152/ajpregu.00124.2011. Epub 2011 Jul 13.

Renal proximal tubule angiotensin AT1A receptors regulate blood pressure.

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  • 1Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

Abstract

All components of the renin angiotensin system necessary for ANG II generation and action have been reported to be present in renal proximal convoluted tubules. Given the close relationship between renal sodium handling and blood pressure regulation, we hypothesized that modulating the action of ANG II specifically in the renal proximal tubules would alter the chronic level of blood pressure. To test this, we used a proximal tubule-specific, androgen-dependent, promoter construct (KAP2) to generate mice with either overexpression of a constitutively active angiotensin type 1A receptor transgene or depletion of endogenous angiotensin type 1A receptors. Androgen administration to female transgenic mice caused a robust induction of the transgene in the kidney and increased baseline blood pressure. In the receptor-depleted mice, androgen administration to females resulted in a Cre recombinase-mediated deletion of angiotensin type 1A receptors in the proximal tubule and reduced blood pressure. In contrast to the changes observed at baseline, there was no difference in the blood pressure response to a pressor dose of ANG II in either experimental model. These data, from two separate mouse models, provide evidence that ANG II signaling via the type 1A receptor in the renal proximal tubule is a regulator of systemic blood pressure under baseline conditions.

PMID:
21753145
[PubMed - indexed for MEDLINE]
PMCID:
PMC3197336
Free PMC Article

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