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    J Clin Psychiatry. 1990 Dec;51(12):505-7.

    The effect of long-term imipramine treatment on carbon dioxide-induced anxiety in panic disorder patients.

    Woods SW, Charney DS, Delgado PL, Heninger GR.

    Source

    Clinical Neuroscience Research Unit, Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven 06508.

    Abstract

    The authors examined whether long-term treatment with imipramine would decrease CO2-induced anxiety in 10 patients with panic disorder. The patients underwent CO2 testing after single-blind placebo testing and again after imipramine treatment. Scores on self-rated visual analog mood scales and panic attack symptom scales showed that the anxiogenic effects of CO2 were significantly reduced during long-term imipramine treatment. These results suggest that the mechanisms underlying CO2-induced anxiety may be similar to those involved in the pathophysiology of panic disorder.

    PMID:
    2175307
    [PubMed - indexed for MEDLINE]

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