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Int J Vasc Med. 2011;2011:376281. doi: 10.1155/2011/376281. Epub 2011 Jun 16.

The mechanosensory role of primary cilia in vascular hypertension.

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  • 1Colleges of Medicine, Pharmacy and Pharmaceutical Sciences, The University of Toledo, Health Science Campus, HEB 274, 3000 Arlington Avenue MS 1015, Toledo, OH 43614, USA.

Abstract

Local regulation of vascular tone plays an important role in cardiovascular control of blood pressure. Aside from chemical or hormonal regulations, this local homeostasis is highly regulated by fluid-shear stress. It was previously unclear how vascular endothelial cells were able to sense fluid-shear stress. The cellular functions of mechanosensory cilia within vascular system have emerged recently. In particular, hypertension is insidious and remains a continuous problem that evolves during the course of polycystic kidney disease (PKD). The basic and clinical perspectives on primary cilia are discussed with regard to the pathogenesis of hypertension in PKD.

PMID:
21748021
[PubMed]
PMCID:
PMC3124932
Free PMC Article

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