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Arch Neurol. 2011 Jul;68(7):932-7. doi: 10.1001/archneurol.2011.141.

Enlarged substantia nigra hyperechogenicity and risk for Parkinson disease: a 37-month 3-center study of 1847 older persons.

Author information

  • 1Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center of Neurodegenerative Diseases, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany. daniela.berg@uni-tuebingen.de

Abstract

OBJECTIVE:

To evaluate whether enlarged substantia nigra hyperechogenicity (SN+) is associated with an increased risk for Parkinson disease (PD) in a healthy elderly population.

DESIGN:

Longitudinal 3-center observational study with 37 months of prospective follow-up.

SETTING:

Individuals 50 years or older without evidence of PD or any other neurodegenerative disease.

PARTICIPANTS:

Of 1847 participants who underwent a full medical history, neurological assessment, and transcranial sonography at baseline, 1535 could undergo reassessment.

MAIN OUTCOME MEASURE:

Incidence of new-onset PD in relation to baseline transcranial sonography status.

RESULTS:

There were 11 cases of incident PD during the follow-up period. In participants with SN+ at baseline, the relative risk for incident PD was 17.37 (95% confidence interval, 3.71-81.34) times higher compared with normoechogenic participants.

CONCLUSIONS:

In this prospective study, we demonstrate for the first time a highly increased risk for PD in elderly individuals with SN+. Transcranial sonography of the midbrain may therefore be a promising primary screening procedure to define a risk population for imminent PD.

PMID:
21747034
[PubMed - indexed for MEDLINE]
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