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Lipids Health Dis. 2011 Jul 12;10:116. doi: 10.1186/1476-511X-10-116.

Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats.

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  • 1College of Pharmacy, Sahmyook University, Seoul, Republic of Korea.

Abstract

BACKGROUND:

Recent studies have reported the preventive effects of probiotics on obesity. Among commensal bacteria, bifidobacteria is one of the most numerous probiotics in the mammalian gut and are a type of lactic acid bacteria. The aim of this study was to assess the antiobesity and lipid-lowering effects of Bifidobacterium spp. isolated from healthy Korean on high fat diet-induced obese rats.

METHODS:

Thirty-six male Sprague-Dawley rats were divided into three groups as follows: (1) SD group, fed standard diet; (2) HFD group, fed high fat diet; and (3) HFD-LAB group, fed high fat diet supplemented with LAB supplement (B. pseudocatenulatum SPM 1204, B. longum SPM 1205, and B. longum SPM 1207; 108 ~ 109 CFU). After 7 weeks, the body, organ, and fat weights, food intake, blood serum levels, fecal LAB counts, and harmful enzyme activities were measured.

RESULTS:

Administration of LAB reduced body and fat weights, blood serum levels (TC, HDL-C, LDL-C, triglyceride, glucose, leptin, AST, ALT, and lipase levels), and harmful enzyme activities (β-glucosidase, β-glucuronidase, and tryptophanase), and significantly increased fecal LAB counts.

CONCLUSION:

These data suggest that Bifidobacterium spp. used in this study may have beneficial antiobesity effects.

PMID:
21745411
[PubMed - indexed for MEDLINE]
PMCID:
PMC3146849
Free PMC Article
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