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Oral Maxillofac Surg. 2012 Mar;16(1):127-31. doi: 10.1007/s10006-011-0270-0. Epub 2011 Apr 6.

Basal cell carcinoma arising in association with a maxillary keratocyst in a patient with Gorlin-Goltz syndrome. Report of a case.

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  • 1Department of Oral and Maxillofacial Surgery, G. Papanikolaou Hospital, Exohi, Thessaloniki, Ioanni Hatzoudi 9, Neapoli, 56727 Thessaloniki, Greece. lazaridoudm@yahoo.gr

Abstract

INTRODUCTION:

Gorlin-Goltz syndrome, also known as nevoid basal cell carcinoma syndrome, is an autosomal dominant inherited disorder which is characterized by the presence of multiple basal cell carcinomas, maxillary keratocysts, and musculoskeletal anomalies.

CASE REPORT:

We present a case of a patient suffering from Gorlin-Goltz syndrome who developed an intraosseous basal cell carcinoma associated with a recurrent maxillary keratocyst. To our knowledge, this is the first case of malignant transformation of a keratocyst into a basal cell carcinoma described in the literature.

CONCLUSION:

This case highlights the importance of careful histologic examination of keratocysts excised in patients suffering from Gorlin-Goltz syndrome.

PMID:
21744042
[PubMed - indexed for MEDLINE]
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