Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2011 Oct;34(10):504-14. doi: 10.1016/j.tins.2011.06.003. Epub 2011 Aug 20.

An opportunistic theory of cellular and systems consolidation.

Author information

  • 1University of California, San Diego, Department of Psychiatry 9116a, 3350 La Jolla Village Drive, San Diego, CA 92116, USA. smednick@ucsd.edu

Abstract

Memories are often classified as hippocampus dependent or independent, and sleep has been found to facilitate both, but in different ways. In this Opinion, we explore the optimal neural state for cellular and systems consolidation of hippocampus-dependent memories that benefit from sleep. We suggest that these two kinds of consolidation, which are ordinarily treated separately, overlap in time and jointly benefit from a period of reduced interference (during which no new memories are formed). Conditions that result in reduced interference include slow wave sleep (SWS), NMDA receptor antagonists, benzodiazepines, alcohol and acetylcholine antagonists. We hypothesize that the consolidation of hippocampal-dependent memories might not depend on SWS per se. Instead, the brain opportunistically consolidates previously encoded memories whenever the hippocampus is not otherwise occupied by the task of encoding new memories.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21742389
[PubMed - indexed for MEDLINE]
PMCID:
PMC3183157
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk