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Stroke. 2011 Aug;42(8):2342-50. doi: 10.1161/STROKEAHA.111.613422. Epub 2011 Jul 7.

Restoring neuronal function after stroke by cell replacement: anatomic and functional considerations.

Author information

  • 1Heinrich-Heine-University, Duesseldorf, Germany. marcel.dihne@uni-duesseldorf.de

Abstract

BACKGROUND AND PURPOSE:

A major challenge to effective treatment after stroke is the restoration of neuronal function. In recent years, cell-based therapies for stroke have been explored in experimental animal models, and the results have suggested behavioral improvements. However, the anatomic targets of a cell-based stroke therapy and the relationship of cell grafts to post stroke reorganization are poorly understood, which results in difficulties defining strategies for neuronal substitution. Given that stroke causes a variety of secondary changes at locations beyond the infarct lesion, overcoming these difficulties is even more important.

SUMMARY OF REVIEW:

We describe which brain structures and cell types are candidates for substitution and how new neuronal functionality could be implemented in a damaged brain by capitalizing on current concepts of post stroke plasticity.

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