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Trends Parasitol. 2011 Oct;27(10):434-41. doi: 10.1016/j.pt.2011.05.006. Epub 2011 Jul 6.

Gene expression in Trypanosoma brucei: lessons from high-throughput RNA sequencing.

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  • 1Biology of Host-Parasite Interactions, Parasitology, Institut Pasteur, 75724 Paris, France.

Abstract

Trypanosoma brucei undergoes major biochemical and morphological changes during its development from the bloodstream form in the mammalian host to the procyclic form in the midgut of its insect host. The underlying regulation of gene expression, however, is poorly understood. More than 60% of the predicted genes remain annotated as hypothetical, and the 5' and 3' untranslated regions important for regulation of gene expression are unknown for >90% of the genes. In this review, we compare the data from four recently published high-throughput RNA sequencing studies in light of the different experimental setups and discuss how these data can enhance genome annotation and give insights into the regulation of gene expression in T. brucei.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21737348
[PubMed - indexed for MEDLINE]
PMCID:
PMC3178736
Free PMC Article

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