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Am J Trop Med Hyg. 2011 Jul;85(1):162-8. doi: 10.4269/ajtmh.2011.10-0469.

Distribution and phylogenetic comparisons of a novel mosquito flavivirus sequence present in Culex tarsalis Mosquitoes from western Canada with viruses isolated in California and Colorado.

Author information

  • 1National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada. shaun.tyler@phac-aspc.gc.ca

Abstract

In a previous study, a new flavivirus genome sequence was identified in Culex tarsalis mosquitoes obtained in Alberta, Canada and was shown to be genetically related to but distinct from members of the insect-specific flaviviruses. Nonstructural protein 5-encoding sequences amplified from Cx. tarsalis pools from western Canada have shown a high similarity to genome sequences of novel flaviviruses isolated from mosquitoes in California and Colorado. Despite wide distribution of this virus, designated Calbertado virus, strains demonstrate a high degree of nonstructural protein 5 nucleotide (> 90%) and amino acid (> 97%) identity. The ecology and geographic range of Calbertado virus warrants further study because it may potentially influence transmission of mosquito-borne flaviviruses, including important human pathogens such as West Nile and Saint Louis encephalitis viruses.

PMID:
21734143
[PubMed - indexed for MEDLINE]
PMCID:
PMC3122362
Free PMC Article

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