Send to

Choose Destination
See comment in PubMed Commons below
Trends Immunol. 2011 Aug;32(8):373-9. doi: 10.1016/ Epub 2011 Jul 4.

NLRP3 inflammasomes link inflammation and metabolic disease.

Author information

  • 1Institute of Innate Immunity, University Hospitals, Biomedical Centre, University of Bonn, Germany.


A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.

Copyright © 2011 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk