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Trends Immunol. 2011 Aug;32(8):373-9. doi: 10.1016/j.it.2011.05.004. Epub 2011 Jul 4.

NLRP3 inflammasomes link inflammation and metabolic disease.

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  • 1Institute of Innate Immunity, University Hospitals, Biomedical Centre, University of Bonn, Germany.

Abstract

A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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