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J Periodontal Res. 2011 Dec;46(6):691-6. doi: 10.1111/j.1600-0765.2011.01391.x. Epub 2011 Jul 6.

Effects of induced diabetes and the administration of aminoguanidine in the biomechanical retention of implants: a study in rats.

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  • 1Pontifícia Universidade Católica de Minas Gerais (PUC-MG), Santa Efigênia, Brasil. rportog@gmail.com

Abstract

BACKGROUND AND OBJECTIVE:

The present study aimed to assess the effects of induced diabetes and the administration of aminoguanidine in the biomechanical retention of implants in rats.

MATERIAL AND METHODS:

Thirty-six rats were randomly divided into six groups: group 1, healthy rats (no aminoguanidine); group 2 and group 3, healthy rats receiving 10 and 20 mg/kg of aminoguanidine daily, respectively; group 4, diabetic rats (no aminoguanidine); and group 5 and group 6, diabetic rats receiving 10 and 20 mg/kg of aminoguanidine daily, respectively. In each rat an implant was inserted in the femur. After 28 d of healing, the rats were killed. The implants were removed by applying a counter-torque, and the maximum force required for the rupture of the bone-implant interface was recorded using an analog torque meter. The data were evaluated using analysis of variance and the Student's t-test.

RESULTS:

In the healthy groups, no statistically significant difference could be observed in the average counter-torque values for implant removal, whereas in the diabetic groups, a daily dose of 20 mg/kg of aminoguanidine raised the counter-torque values to the values found in healthy rats.

CONCLUSION:

The administration of 20 mg/kg of aminoguanidine daily in diabetic rats raised the biomechanical retention of the implants to the level observed in the healthy rat group.

© 2011 John Wiley & Sons A/S.

PMID:
21732947
[PubMed - indexed for MEDLINE]
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