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Cell. 2011 Jul 8;146(1):18-36. doi: 10.1016/j.cell.2011.06.030.

Development and evolution of the human neocortex.

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  • 1Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA 94143, USA.

Erratum in

  • Cell. 2011 Jul 22;146(2):332.

Abstract

The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show that development of the gyrated human neocortex involves a lineage of neural stem and transit-amplifying cells that forms the outer subventricular zone (OSVZ), a proliferative region outside the ventricular epithelium. We discuss how proliferation of cells within the OSVZ expands the neocortex by increasing neuron number and modifying the trajectory of migrating neurons. Relating these features to other mammalian species and known molecular regulators of the mouse neocortex suggests how this developmental process could have emerged in evolution.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21729779
[PubMed - indexed for MEDLINE]
PMCID:
PMC3610574
Free PMC Article
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