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Eukaryot Cell. 2011 Nov;10(11):1396-402. doi: 10.1128/EC.05087-11. Epub 2011 Jul 1.

Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans.

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  • 1Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.


Calcineurin is a calcium-calmodulin-activated serine/threonine-specific phosphatase that operates during cellular responses to stress and plays a prominent role in transcriptional control, whereas regulatory events beyond transcription are less well characterized. This study reveals a novel transcription-independent role of calcineurin during the temperature stress response in the human fungal pathogen Cryptococcus neoformans. The diffusely cytoplasmic calcineurin catalytic subunit Cna1 relocates to endoplasmic reticulum (ER)-associated puncta and the mother-bud neck when cells are subjected to 37°C. More than 50% of Cna1 puncta contain the P-body constituent decapping enzyme Dcp1 and the stress granule constituent poly(A)-binding protein Pub1. These results support a model in which calcineurin orchestrates thermal stress responses by associating with sites of mRNA processing.

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