Cancer Lett. 2011 Oct 28;309(2):128-36. Epub 2011 Jun 24.

Epstein-Barr virus and breast cancer: serological study in a high-incidence area of nasopharyngeal carcinoma.

He JR, Tang LY, Yu DD, Su FX, Song EW, Lin Y, Wang SM, Lai GC, Chen WQ, Ren ZF.

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The School of Public Health, Sun Yat-Sen University, 74 Zhongshan 2nd Rd., Guangzhou 510080, China.

Abstract

We investigated IgA and IgG levels against EBV viral capsid antigen (VCA) and nuclear antigen-1 (EBNA-1) in serum of 223 women with breast cancer (BC) and 309 controls in Guangzhou, China. VCA IgA levels were significantly associated with an elevated risk of BC, with adjusted ORs (95%CIs) of 1.70 (1.05-2.76) (seropositivity) and 2.21 (1.11-4.40) (unit increases in OD value). This association was stronger among young, lean, and HER2+ women. The EBNA-1 IgA levels in OD value, but not seropositivity, were associated with an increased risk of BC among ER+, PR+, and HER2+ patients. None of the IgG variables was related to BC. These results suggest the EBV association with BC in an endemic area of nasopharyngeal carcinoma.

PMID:: 21724319; [PubMed - indexed for MEDLINE]

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Nasopharyngeal carcinoma

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