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J Neurooncol. 2011 Dec;105(3):451-66. doi: 10.1007/s11060-011-0658-6. Epub 2011 Jul 1.

The roles of viruses in brain tumor initiation and oncomodulation.

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  • 1Department of Microbiology, University of Virginia, P.O. Box 800168, Charlottesville, VA 22908, USA.

Abstract

While some avian retroviruses have been shown to induce gliomas in animal models, human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract more and more attention as possible contributing or initiating factors in the development of human brain tumors. The aim of this review is to summarize and highlight the most provoking findings indicating a potential causative link between brain tumors, specifically malignant gliomas, and viruses in the context of the concepts of viral oncomodulation and the tumor stem cell origin.

PMID:
21720806
[PubMed - indexed for MEDLINE]
PMCID:
PMC3278219
Free PMC Article
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