Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Exp Ophthalmol. 2010 Sep 29;1(103). pii: 1000103.

Management of Corneal Graft Rejection - A Case Series Report and Review of the Literature.

Author information

  • 1Doheny Eye Institute and the Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.

Abstract

PURPOSE:

To report long-term results in a case series of patients treated with systemic immune suppression for prevention of penetrating keratoplasty (PKP) graft rejection.

DESIGN:

Retrospective noncomparative chart review.

PARTICIPANTS:

Three patients presented with PKP graft failure.

METHODS:

Patients received oral prednisone, azathioprine and cyclosporine to prevent rejection of repeat corneal transplant. Patients received repeat PKP and graft outcome was reported.

MAIN OUTCOME MEASURES:

Visual acuity and graft survival were recorded.

RESULTS:

Mean age was 55 years, two male and one female. Mean follow-up period was 37 months (range 24-46). All three patients completed the treatment protocol with minimal adverse effects. All grafts remained clear over observational period.

CONCLUSION:

Our study suggests that systemic immune suppression with 2 or more agents may be helpful to prevent corneal graft rejection in high-risk patients.

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk