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Head Neck. 2012 May;34(5):649-54. doi: 10.1002/hed.21793. Epub 2011 Jun 29.

Trends in the incidence of oral cavity and oropharyngeal cancers in Spain.

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  • 1Departamento de Microbiología, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, España.



The purpose of this study was to analyze and compare incidence trends of oral cavity and oropharyngeal cancers, using data from population-based Spanish cancer registries.


Adjusted rates were calculated using the standard world population, and incidence trends were analyzed for individual and pooled registries using joinpoint regression.


Analysis of 7 pooled registries revealed a statistically significant reduction in the incidence of oral cavity cancer in men (annual percent change [APC] = -3.1) and a nonsignificant decrease in women (APC = -4.5) over the period from 1991 to 2001. For oropharyngeal cancer, the trend was for a statistically significant increase in men in 4 registries.


There is growing evidence that the incidence of oral cavity cancer is in decline, while the incidence of oropharyngeal cancer has been increasing over the past 3 decades, especially in developed countries, and this study reinforces such evidence.

Copyright © 2011 Wiley Periodicals, Inc.

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