AIDS. 2011 Oct 23;25(16):2005-8. doi: 10.1097/QAD.0b013e32834a36d0.

Preexposure prophylaxis and timed intercourse for HIV-discordant couples willing to conceive a child.

Vernazza PL, Graf I, Sonnenberg-Schwan U, Geit M, Meurer A.

Source

Division of Infectious Diseases, Kantonsspital St Gallen, Switzerland. Pietro.Vernazza@kssg.ch

Abstract

Many HIV-discordant couples express a strong wish to conceive a child. Insemination with processed semen is offered to these couples in many countries. Given the very low level of transmission risk during fully suppressive antiretroviral therapy, we offered timed intercourse combined with preexposure prophylaxis to further reduce the transmission risk. In 53 cases, natural conception was attempted using the proposed method. Pregnancy rates were high and reached a plateau of 75% after six cycles. Advanced age in the female partner was a predictor for infertility in these couples.

Comment in

Antiretrovirals for safer conception for HIV-negative women and their HIV-1-infected male partners: how safe and how available? [AIDS. 2011]
Antiretrovirals for safer conception for HIV-negative women and their HIV-1-infected male partners: how safe and how available?Mastro TD, Cohen MS, Rees H. AIDS. 2011 Oct 23; 25(16):2049-51.

PMID:: 21716070; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Save items

Related citations in PubMed

Achieving safe conception in HIV-discordant couples: the potential role of oral preexposure prophylaxis (PrEP) in the United States. [Am J Obstet Gynecol. 2011]
Achieving safe conception in HIV-discordant couples: the potential role of oral preexposure prophylaxis (PrEP) in the United States.
Lampe MA, Smith DK, Anderson GJ, Edwards AE, Nesheim SR. Am J Obstet Gynecol. 2011 Jun; 204(6):488.e1-8. Epub 2011 Mar 31.
Review Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples. [Cochrane Database Syst Rev. 2011]
Review Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples.
Anglemyer A, Rutherford GW, Egger M, Siegfried N. Cochrane Database Syst Rev. 2011 May 11; (5):CD009153. Epub 2011 May 11.
Review Antiretrovirals and safer conception for HIV-serodiscordant couples. [Curr Opin HIV AIDS. 2012]
Review Antiretrovirals and safer conception for HIV-serodiscordant couples.
Matthews LT, Smit JA, Cu-Uvin S, Cohan D. Curr Opin HIV AIDS. 2012 Nov; 7(6):569-78.
Review Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples. [Cochrane Database Syst Rev. 2011]
Review Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples.
Anglemyer A, Rutherford GW, Baggaley RC, Egger M, Siegfried N. Cochrane Database Syst Rev. 2011 Aug 10; (8):CD009153. Epub 2011 Aug 10.
Antiretrovirals for safer conception for HIV-negative women and their HIV-1-infected male partners: how safe and how available? [AIDS. 2011]
Antiretrovirals for safer conception for HIV-negative women and their HIV-1-infected male partners: how safe and how available?
Mastro TD, Cohen MS, Rees H. AIDS. 2011 Oct 23; 25(16):2049-51.

See reviews... See all...

Cited by 6 PubMed Central articles

The cost and impact of scaling up pre-exposure prophylaxis for HIV prevention: a systematic review of cost-effectiveness modelling studies. [PLoS Med. 2013]
The cost and impact of scaling up pre-exposure prophylaxis for HIV prevention: a systematic review of cost-effectiveness modelling studies.
Gomez GB, Borquez A, Case KK, Wheelock A, Vassall A, Hankins C. PLoS Med. 2013 Mar; 10(3):e1001401. Epub 2013 Mar 12.
Women with pregnancies had lower adherence to 1% tenofovir vaginal gel as HIV preexposure prophylaxis in CAPRISA 004, a phase IIB randomized-controlled trial. [PLoS One. 2013]
Women with pregnancies had lower adherence to 1% tenofovir vaginal gel as HIV preexposure prophylaxis in CAPRISA 004, a phase IIB randomized-controlled trial.
Matthews LT, Sibeko S, Mansoor LE, Yende-Zuma N, Bangsberg DR, Karim QA. PLoS One. 2013; 8(3):e56400. Epub 2013 Mar 5.
A conceptual framework for understanding HIV risk behavior in the context of supporting fertility goals among HIV-serodiscordant couples. [Reprod Health Matters. 2012]
A conceptual framework for understanding HIV risk behavior in the context of supporting fertility goals among HIV-serodiscordant couples.
Crankshaw TL, Matthews LT, Giddy J, Kaida A, Ware NC, Smit JA, Bangsberg DR. Reprod Health Matters. 2012 Dec; 20(39 Suppl):50-60.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Preexposure prophylaxis and timed intercourse for HIV-discordant couples willing...
Preexposure prophylaxis and timed intercourse for HIV-discordant couples willing to conceive a child.
AIDS. 2011 Oct 23 ;25(16):2005-8. doi: 10.1097/QAD.0b013e32834a36d0.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Preexposure prophylaxis and timed intercourse for HIV-discordant couples willing to conceive a child.

Source

Abstract

Comment in

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 6 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information