Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA. igor-dozmorov@omrf.org
In this work we apply the Internal Standard-based analytical approach that we described in an earlier communication and here we demonstrate experimental results on functional associations among the hypervariably-expressed genes (HVE-genes). Our working assumption was that those genetic components, which initiate the disease, involve HVE-genes for which the level of expression is undistinguishable among healthy individuals and individuals with pathology. We show that analysis of the functional associations of the HVE-genes is indeed suitable to revealing disease-specific differences. We show also that another possible exploit of HVE-genes for characterization of pathological alterations is by using multivariate classification methods. This in turn offers important clues on naturally occurring dynamic processes in the organism and is further used for dynamic discrimination of groups of compared samples. We conclude that our approach can uncover principally new collective differences that cannot be discerned by individual gene analysis.
Images from this publication.See all images (10) Free text
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on