High density lipoprotein is a scavenger of superoxide anions

Biochem Pharmacol. 1990 Oct 1;40(7):1663-5. doi: 10.1016/0006-2952(90)90469-2.

Abstract

Present work describes a new property of HDL to act as a scavenger of O2- free radicals in vitro. This lipoprotein prevents both enzymic and non-enzymic generation of O2- anions as evidenced by inhibition of xanthine oxidase, peroxidase, peroxidation of pyrogallol and phenazine methosulphate-NADH reaction. Ascorbate stimulated MDA formation in microsomes has been shown to be suppressed by HDL and these effects are comparable with that of BHA.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anions / metabolism
  • Ascorbic Acid / metabolism
  • Butylated Hydroxyanisole / pharmacology
  • Free Radical Scavengers*
  • Humans
  • Lipid Peroxidation / drug effects
  • Lipoproteins, HDL / pharmacology*
  • Malondialdehyde / metabolism
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism*
  • NADP / metabolism
  • Peroxidase / metabolism
  • Rats
  • Superoxides / metabolism*
  • Xanthine Oxidase / metabolism

Substances

  • Anions
  • Free Radical Scavengers
  • Lipoproteins, HDL
  • Superoxides
  • Butylated Hydroxyanisole
  • Malondialdehyde
  • NADP
  • Peroxidase
  • Xanthine Oxidase
  • Ascorbic Acid