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J Carcinog. 2011;10:14. doi: 10.4103/1477-3163.79683. Epub 2011 Apr 16.

Elevated levels of urinary 8-hydroxy-2'-deoxyguanosine and 8-isoprostane in esophageal squamous cell carcinoma.

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  • 1Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Abstract

AIMS:

To measure oxidative DNA and lipid damages, urinary levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), and 8-isoprostane in esophageal squamous cell carcinoma (SCC) patients and compare the values with that in controls.

MATERIALS AND METHODS:

The urinary concentrations of 8-OHdG and 8-isoprostane were measured in 32 SCC patients (13 female/19 male; mean age: 61.4 ± 10.5 years) and 45 controls (22 female/23 male; mean age: 58.1 ± 8.3 years).

RESULTS:

Squamous cell carcinoma patients showed significantly higher levels of urinary 8-OHdG (15.6 ± 5.1 ng/mg creatinine) than controls (5.8 ± 2.1 ng/mg creatinine) (P<.001). Increased urinary concentrations of 8-isoprostane were also detected in SCC patients (35.4 ± 6.5 ng/mmol creatinine) as compared to the controls (16.9 ± 4.0 ng/mmol creatinine) (P<.001).

CONCLUSIONS:

Our results show the presence of oxidative DNA and lipid damage in the SCC patients. This may have a connection to carcinogenesis in the esophagus.

KEYWORDS:

8-hydroxy-2′-deoxyguanosine; 8-isoprostane; Esophageal squamous cell carcinoma

PMID:
21712961
[PubMed]
PMCID:
PMC3122113
Free PMC Article

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