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Cell Biosci. 2011 Apr 4;1(1):15. doi: 10.1186/2045-3701-1-15.

Subretinal gene delivery using helper-dependent adenoviral vectors.

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  • 1Physiology and Experimental Medicine Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G1X8, Canada. jim.hu@utoronto.ca.

Abstract

This study describes the successful delivery of helper-dependent adenoviral vectors to the mouse retina with long term and robust levels of reporter expression in the retina without apparent adverse effects. Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector.

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