Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Anticancer Agents Med Chem. 2012 Jan;12(1):40-8.

Targeting cancer using fragment based drug discovery.

Author information

  • 1CRT Discovery Laboratories, Department of Crystallography, Birkbeck College, University of London, Malet Street, London, WC1E 7HX. aturnbull@cancertechnology.com

Abstract

Over the past decade, fragment-based drug discovery has developed significantly and has gained increasing popularity in the pharmaceutical industry as a powerful alternative and complement to traditional high-throughput screening approaches for hit identification. Fragment-based methods are capable of rapidly identifying starting points for structure-based drug design from relatively small libraries of low molecular weight compounds. The main constraints are the need for sensitive methods that can reliably detect the typically weak interactions between fragments and the target protein, and strategies for transforming fragments into higher molecular weight drug candidates. This approach has recently been validated as series of compounds from various programs have entered clinical trials.

PMID:
21707503
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Bentham Science Publishers Ltd.
    Loading ...
    Write to the Help Desk