Evid Based Med. 2011 Aug;16(4):124-5. doi: 10.1136/ebm1203. Epub 2011 Jun 24.

Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel.

Ramirez AH, Delaney JT, Shuldiner AR.

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Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. [JAMA. 2010]
Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis.Mega JL, Simon T, Collet JP, Anderson JL, Antman EM, Bliden K, Cannon CP, Danchin N, Giusti B, Gurbel P, et al. JAMA. 2010 Oct 27; 304(16):1821-30.

PMID:: 21705400; [PubMed]

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Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. [JAMA. 2010]
Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis.
Mega JL, Simon T, Collet JP, Anderson JL, Antman EM, Bliden K, Cannon CP, Danchin N, Giusti B, Gurbel P, et al. JAMA. 2010 Oct 27; 304(16):1821-30.
Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis. [Lancet. 2010]
Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.
Mega JL, Close SL, Wiviott SD, Shen L, Walker JR, Simon T, Antman EM, Braunwald E, Sabatine MS. Lancet. 2010 Oct 16; 376(9749):1312-9.
Genetic determinants of response to clopidogrel and cardiovascular events. [N Engl J Med. 2009]
Genetic determinants of response to clopidogrel and cardiovascular events.
Simon T, Verstuyft C, Mary-Krause M, Quteineh L, Drouet E, Méneveau N, Steg PG, Ferrières J, Danchin N, Becquemont L, et al. N Engl J Med. 2009 Jan 22; 360(4):363-75. Epub 2008 Dec 22.
Review Benefits and risks of clopidogrel use in patients with coronary artery disease: evidence from randomized studies and registries. [Clin Ther. 2008]
Review Benefits and risks of clopidogrel use in patients with coronary artery disease: evidence from randomized studies and registries.
Motovska Z, Kala P. Clin Ther. 2008; 30 Pt 2:2191-202.
Review Clopidogrel: potential in the prevention of cardiovascular events in patients with acute coronary syndromes. [Am J Cardiovasc Drugs. 2001]
Review Clopidogrel: potential in the prevention of cardiovascular events in patients with acute coronary syndromes.
Easthope SE, Jarvis B. Am J Cardiovasc Drugs. 2001; 1(6):467-74; discussion 475-6.

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Carrying one or two reduced-function CYP2C19 alleles is associated with an incre...
Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel.
Evid Based Med. 2011 Aug ;16(4):124-5. doi: 10.1136/ebm1203. Epub 2011 Jun 24 .

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Carrying one or two reduced-function CYP2C19 alleles is associated with an increased risk of major adverse cardiovascular events in people undergoing percutaneous coronary intervention and treated with clopidogrel.

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