Trends Endocrinol Metab. 2011 Sep;22(9):374-81. Epub 2011 Jun 22.

Stressed out about obesity: IRE1α-XBP1 in metabolic disorders.

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Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.

Abstract

The global obesity epidemic is associated with a series of health-threatening diseases including type 2 diabetes. Accumulating evidence suggest that the physiology and homeostasis of the endoplasmic reticulum (ER) is intimately involved in the underlying mechanisms linking obesity and diabetes. Specifically, recent studies indicate a crucial role for the inositol-requiring enzyme 1α (IRE1α)/X-box binding protein 1 (XBP1) pathway, the most conserved branch of the unfolded protein response (UPR), in glucose and lipid metabolism as well as in insulin function. Focusing on the IRE1α-XBP1 pathway, we review recent advances in our understanding of the role of UPR in obesity and obesity-associated metabolic disorders.

PMID:: 21703863; [PubMed - indexed for MEDLINE]
PMCID:: PMC3163776; [Available on 2012/9/1]

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Stressed out about obesity: IRE1α-XBP1 in metabolic disorders.
Stressed out about obesity: IRE1α-XBP1 in metabolic disorders.
Trends Endocrinol Metab. 2011 Sep ;22(9):374-81. Epub 2011 Jun 22 .

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