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PM R. 2011 Jun;3(6 Suppl 1):S18-27. doi: 10.1016/j.pmrj.2011.03.017.

Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitation.

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  • 1Department of Physical Medicine and Rehabilitation, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, USA.


Neuroplastic changes, whether induced by traumatic brain injury (TBI) or therapeutic interventions, alter neurobehavioral outcome. Here we present several treatment strategies that have been evaluated by using experimental TBI models and discuss potential mechanisms of action (ie, plasticity) and how such changes affect function.

Copyright © 2011 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

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