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Immunity. 2011 Jun 24;34(6):825-7. doi: 10.1016/j.immuni.2011.06.004.

Lymphocyte signaling converges on microtubules.

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  • 1Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.


Movement of immunoreceptor microclusters tunes lymphocyte activation, but the underlying mechanisms are incompletely understood. In this issue of Immunity, Schnyder et al. (2011) and Hashimoto-Tane et al. (2011) show that cytoplasmic dynein drives microcluster centralization along microtubules.

Copyright © 2011 Elsevier Inc. All rights reserved.

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