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Diabetes. 2011 Aug;60(8):2197-201. doi: 10.2337/db10-1645. Epub 2011 Jun 23.

Novel locus FER is associated with serum HMW adiponectin levels.

Author information

  • 1Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. nhlqi@channing.harvard.edu

Abstract

OBJECTIVE:

High molecular weight (HMW) adiponectin is a predominant isoform of circulating adiponectin and has been related to type 2 diabetes. Previous linkage studies suggest that different genetic components might be involved in determining HMW and total adiponectin levels.

RESEARCH DESIGN AND METHODS:

We performed a genome-wide association study (GWAS) of serum HMW adiponectin levels in individuals of European ancestry drawn from the Nurses' Health Study (NHS) (N = 1,591). The single nucleotide polymorphisms (SNPs) identified in the GWAS analysis were replicated in an independent cohort of Europeans (N = 626). We examined the associations of the identified variations with diabetes risk and metabolic syndrome.

RESULTS:

We identified a novel locus near the FER gene (5q21) at a genome-wide significance level, best represented by SNP rs10447248 (P = 4.69 × 10(-8)). We also confirmed that variations near the adiponectin-encoding ADIPOQ locus (3q27) were related to serum HMW adiponectin levels. In addition, we found that FER SNP rs10447248 was related to HDL cholesterol levels (P = 0.009); ADIPOQ variation was associated with fasting glucose (P = 0.04), HDL cholesterol (P = 0.04), and a metabolic syndrome score (P = 0.002).

CONCLUSIONS:

Our results suggest that different loci may be involved in regulation of circulating HMW adiponectin levels and provide novel insight into the mechanisms that affect HMW adiponectin homeostasis.

PMID:
21700879
[PubMed - indexed for MEDLINE]
PMCID:
PMC3142072
Free PMC Article
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