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Science. 2011 Jun 24;332(6037):1576-81. doi: 10.1126/science.1202839.

Sleep and synaptic homeostasis: structural evidence in Drosophila.

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  • 1Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA.

Abstract

The functions of sleep remain elusive, but a strong link exists between sleep need and neuronal plasticity. We tested the hypothesis that plastic processes during wake lead to a net increase in synaptic strength and sleep is necessary for synaptic renormalization. We found that, in three Drosophila neuronal circuits, synapse size or number increases after a few hours of wake and decreases only if flies are allowed to sleep. A richer wake experience resulted in both larger synaptic growth and greater sleep need. Finally, we demonstrate that the gene Fmr1 (fragile X mental retardation 1) plays an important role in sleep-dependent synaptic renormalization.

PMID:
21700878
[PubMed - indexed for MEDLINE]
PMCID:
PMC3128387
Free PMC Article
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