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Science. 2011 Jun 24;332(6037):1554-7. doi: 10.1126/science.1204349.

Gametogenesis eliminates age-induced cellular damage and resets life span in yeast.

Author information

  • 1David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Eukaryotic organisms age, yet detrimental age-associated traits are not passed on to progeny. How life span is reset from one generation to the next is not known. We show that in budding yeast resetting of life span occurs during gametogenesis. Gametes (spores) generated by aged cells show the same replicative potential as gametes generated by young cells. Age-associated damage is no longer detectable in mature gametes. Furthermore, transient induction of a transcription factor essential for later stages of gametogenesis extends the replicative life span of aged cells. Our results indicate that gamete formation brings about rejuvenation by eliminating age-induced cellular damage.

Comment in

  • Ageing: recapturing youth. [Nat Rev Mol Cell Biol. 2011]
PMID:
21700873
[PubMed - indexed for MEDLINE]
PMCID:
PMC3923466
Free PMC Article

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