Synthesis of hydrogels based on poly(NIPAM) inserted into collagen sponge

Colloids Surf B Biointerfaces. 2011 Oct 15;87(2):382-90. doi: 10.1016/j.colsurfb.2011.05.046. Epub 2011 Jun 22.

Abstract

The study presents the preparation of a semi-synthetic hydrogel based on poly(N-isopropyl acrylamide-co-diethylene glycol diacrylate) inserted onto the collagen porous membrane. The synthesis of the hydrogels was performed through radical copolymerization of N-isopropyl acrylamide (NIPAM) with diethylene glycol diacrylate (DEGDA) also as crosslinking agent, using ammonium persulfate as initiator and N,N,N',N'-tetramethylethylene diamine as activator, and it was achieved in the presence of the collagen matrix. The prepared hydrogels were characterized by Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy and Scanning Electron Microscopy. The swelling behaviour of the semi-interpenetrated polymer network related on the hydrogel composition, it was also evaluated. The pore sizes of the synthesized hydrogels, much larger than the typical mesh size of a conventional hydrogel, allow to consider the hybrid hydrogel based on the inserted poly(NIPAM-co-DEGDA) onto collagen fibrils as a super-porous hydrogel.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamides / chemistry
  • Acrylates / chemistry
  • Biocompatible Materials / analysis
  • Biocompatible Materials / chemical synthesis*
  • Collagen / analysis
  • Collagen / chemistry*
  • Collagen / ultrastructure
  • Drug Carriers / analysis
  • Drug Carriers / chemical synthesis*
  • Ethylene Glycol / chemistry
  • Humans
  • Hydrogels / analysis
  • Hydrogels / chemical synthesis*
  • Microscopy, Electron, Scanning
  • Porosity
  • Spectroscopy, Fourier Transform Infrared
  • Wound Healing

Substances

  • Acrylamides
  • Acrylates
  • Biocompatible Materials
  • Drug Carriers
  • Hydrogels
  • Collagen
  • N-isopropylacrylamide
  • Ethylene Glycol
  • acrylic acid