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Epilepsy Res. 2011 Sep;96(1-2):172-5. doi: 10.1016/j.eplepsyres.2011.05.012. Epub 2011 Jun 22.

The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms.

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  • 1Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Abstract

The ketogenic diet (KD) is a treatment of infantile spasms (IS). Here, we examine the efficacy of KD in medically refractory IS, examine its impact on growth in infants, and explore its mechanism of action. At 1-3 months after the initiation of the KD, 46% of twenty-six patients had a greater than 90% reduction in IS. No significant relationships between reduction in IS and serum β-hydroxybutyrate, or glucose levels were identified. Also, the KD had not significantly altered patient's growth parameters. Thus, in corroborating with prior studies, we demonstrate the KD is a well-tolerated and efficacious treatment of IS.

Copyright © 2011 Elsevier B.V. All rights reserved.

PMID:
21700429
[PubMed - indexed for MEDLINE]
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