Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Epilepsy Res. 2011 Sep;96(1-2):172-5. doi: 10.1016/j.eplepsyres.2011.05.012. Epub 2011 Jun 22.

The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms.

Author information

  • 1Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.


The ketogenic diet (KD) is a treatment of infantile spasms (IS). Here, we examine the efficacy of KD in medically refractory IS, examine its impact on growth in infants, and explore its mechanism of action. At 1-3 months after the initiation of the KD, 46% of twenty-six patients had a greater than 90% reduction in IS. No significant relationships between reduction in IS and serum β-hydroxybutyrate, or glucose levels were identified. Also, the KD had not significantly altered patient's growth parameters. Thus, in corroborating with prior studies, we demonstrate the KD is a well-tolerated and efficacious treatment of IS.

Copyright © 2011 Elsevier B.V. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk