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Mol Cell. 2011 Jun 24;42(6):715-7. doi: 10.1016/j.molcel.2011.06.004.

No country for old misfolded glycoproteins.

Author information

  • Department of Molecular and Cellular Biology, Harvard University, Northwest Labs, Cambridge, MA 02138, USA. vdenic@mcb.harvard.edu

Abstract

Gauss et al. (2011) present evidence that an endoplasmic reticulum (ER) sugar-removing enzyme with a folding sensor subunit enables a stochastic quality control mechanism, which marks with increasing probability misfolded glycoproteins for destruction the longer they reside in the ER.

Copyright © 2011 Elsevier Inc. All rights reserved.

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PMID:
21700217
[PubMed]
PMCID:
PMC3632639
Free PMC Article

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