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Int J Nephrol Renovasc Dis. 2010;3:69-83. Epub 2010 Jun 24.

Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment.

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  • 1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.


Both autosomal dominant and recessive polycystic kidney disease are conditions with severe associated morbidity and mortality. Recent advances in the understanding of the genetic and molecular pathogenesis of both ADPKD and ARPKD have resulted in new, targeted therapies designed to disrupt cell signaling pathways responsible for the abnormal cell proliferation, dedifferentiation, apoptosis, and fluid secretion characteristic of the disease. Herein we review the current understanding of the pathophysiology of these conditions, as well as the current treatments derived from our understanding of the mechanisms of these diseases.

2010 Halvorson et al, publisher and licensee Dove Medical Press Ltd.


Polycystic kidney disease; autosomal dominant; end stage renal disease; recessive

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