J Clin Pharmacol. 1990 Aug;30(8):699-703.

Dietary fiber for reducing blood cholesterol.

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Department of Medicine and Epidemiology, Albert Einstein College of Medicine, Bronx, New York.

Abstract

Soluble dietary fiber, including psyllium, has been shown to have mild to modest cholesterol lowering properties. Psyllium hydrophilic mucilloid (Metamucil, Procter and Gamble, Cincinnati, OH), a bulk laxative, when used as a dietary supplement in combination with a low fat diet, can lower total serum cholesterol and low-density lipoprotein (LDL) cholesterol, and raise high-density lipoprotein (HDL) cholesterol in hypercholesterolemic patients. The cholesterol lowering effects of psyllium are much less evident than those observed with cholestyramine and the HMG-CoA reductase inhibitors. The mechanism for the cholesterol lowering effect of psyllium is not known. The substance is well tolerated with long-term use.

PMID:: 2169487; [PubMed - indexed for MEDLINE]

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Cholesterol-lowering effects of psyllium-enriched cereal as an adjunct to a prudent diet in the treatment of mild to moderate hypercholesterolemia. [Am J Clin Nutr. 1992]
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Cited by 1 PubMed Central article

Effect of dietary fiber intake on lipoprotein cholesterol levels independent of estradiol in healthy premenopausal women. [Am J Epidemiol. 2011]
Effect of dietary fiber intake on lipoprotein cholesterol levels independent of estradiol in healthy premenopausal women.
Mumford SL, Schisterman EF, Siega-Riz AM, Gaskins AJ, Wactawski-Wende J, VanderWeele TJ. Am J Epidemiol. 2011 Jan 15; 173(2):145-56. Epub 2010 Dec 9.

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