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    Cancer Res. 1990 Oct 1;50(19):6291-4.

    Expression of human alpha-actinin in human hepatocellular carcinoma.

    Nishiyama M, Ozturk M, Frohlich M, Mafune K, Steele G Jr, Wands JR.

    Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center, Charlestown 02129.

    Little is known regarding gene expression during hepatocyte transformation. We have isolated an alpha-actinin complementary DNA from a human hepatocellular carcinoma library. This partial 2.4-kilobase complementary DNA has high homology with human placental and chicken nonmuscle alpha-actinins; our isolate contains the entire 3' noncoding region and it is within these sequences where the major differences between the vertebrate alpha-actinin complementary DNAs arise. Northern analysis revealed a 3.5-kilobase transcript in nonmuscle and a smaller 3.0-kilobase species in muscle tissue. Levels of alpha-actinin expression were low in normal liver and we investigated its expression during both hepatocyte proliferation and transformation. We found no increase during rat hepatocyte regeneration up to 24 h following two-thirds hepatectomy. However, high levels of alpha-actinin transcripts were observed in human hepatocellular carcinoma compared to noninvolved adjacent liver. We conclude that the alpha-actinin gene is highly expressed when hepatocytes have assumed the malignant phenotype.

    PMID: 2169343 [PubMed - indexed for MEDLINE]

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