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Vet J. 2012 May;192(2):249-51. doi: 10.1016/j.tvjl.2011.05.018.

Lawsonia intracellularis-specific interferon γ gene expression by peripheral blood mononuclear cells in vaccinated and naturally infected foals.

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  • 1Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. npusterla@ucdavis.edu


The cell-mediated immune response to Lawsonia intracellularis, the agent of equine proliferative enteropathy (EPE), was investigated in vaccinated and naturally infected foals. Interferon (IFN)-γ gene expression was determined in peripheral blood mononuclear cells collected from vaccinated (n=6) and control foals (n=6) every 30 days for 180 days following first vaccine administration, and from clinically affected foals (n=16) within 7-10 days of diagnosing EPE. Seroconversion (immunoperoxidase monolayer assay titer ≥60) occurred in 5/6 vaccinated foals between 60 and 90 days following the first vaccine administration and these foals remained seropositive for the remaining study period. IFN-γ gene expression in all vaccinated foals was significantly higher (P<0.05) on days 60-180 following first vaccine administration compared to IFN-γ gene expression in control foals. When IFN-γ gene transcription was compared between naturally infected and vaccinated foals, a significant difference (P<0.05) was observed only for day 0.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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