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J Pharm Bioallied Sci. 2011 Apr;3(2):226-9. doi: 10.4103/0975-7406.80776.

In vitro antimicrobial activity of methanolic leaf extract of Psidium guajava L.

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  • 1Department of Pharmaceutical Sciences, M.D. University, Rohtak, Haryana, India.

Abstract

AIM:

This study was designed to examine the chemical composition and in vitro antimicrobial potential of methanolic extract of Psidium guajava Linn (Myrtaceae).

MATERIALS AND METHODS:

The inhibitory effect of methanolic extract of P. guajava was tested against three bacterial and two fungal strains by using the paper disc diffusion method.

RESULTS:

The methanolic extract exhibited antibacterial activity against E. coli with minimum inhibitory concentration, 0.78 μg/ml, minimum bactericidal concentration of 50 μg/ml, and appreciable antifungal activity with minimum inhibitory concentration of 12.5 μg/ml. Preliminary phytochemical analysis of methanolic extract revealed the presence of antimicrobial compounds such as flavonoids, steroids, and tannins, which may contribute for the antimicrobial action of P. guajava.

CONCLUSION:

The extract was found to be bacteriostatic and fungistatic in action.

KEYWORDS:

Antimicrobial activity; Psidium guajava; paper disc diffusion method

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