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BMJ Case Rep. 2009;2009. pii: bcr06.2008.0235. doi: 10.1136/bcr.06.2008.0235. Epub 2009 Mar 17.

Neuro-regression in vitamin B12 deficiency.

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  • 1Ekta Institute of Child Health, Pediatrics, Near Ram Mandir, Shantinagar, Raipur 492001, India.


Neuroregression in infants has varied aetiology and vitamin B12 deficiency is one of the uncommon causes. Infantile vitamin B12 deficiency is encountered in malnourished infants or in offspring of strict vegan mothers. We present two cases, both infants of 10 and 8 months of age, whose mothers had vitamin B12 deficiency. On admission, the patients were apathic, hypotonic and lethargic. Serum vitamin B12 levels were below normal limits. On cranial MRI, T2-weighted images revealed frontoparietal cortical atrophy. Both the infants responded to vitamin B12 treatment.

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