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BMJ Case Rep. 2009;2009. pii: bcr08.2008.0709. doi: 10.1136/bcr.08.2008.0709. Epub 2009 Feb 2.

Hypocretinergic dysfunction in neuromyelitis optica with coma-like episodes.

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  • 1Department of Neurology, Hôpital Gui-de-Chauliac, Montpellier, France.

Abstract

Devic's neuromyelitis optica (NMO) is a severe demyelinating disease of the central nervous system, often misdiagnosed as multiple sclerosis, and involving mainly optic nerves and the spinal cord. We report on a peculiar case of relapsing NMO with severe recurrent dysautonomia and hypersomnia, in which we had the opportunity to observe a dramatic decrease in hypocretin/orexin cerebrospinal fluid level.

PMID:
21686670
[PubMed]
PMCID:
PMC3029942
Free PMC Article
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