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PAI-1 antagonists: the promise and the peril.

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  • 1Northwestern University Feinberg School of Medicine, Department of Medicine, 201 E. Huron Street, Galter Pavilion, 3rd Floor, Suite 3-150, Chicago, Illinois 60611, USA. d-vaughan@northwestern.edu

Abstract

The plasminogen activator (i.e., fibrinolytic) system is one of the key endogenous defense mechanisms against intravascular thrombosis. Thrombolytic agents represent the only direct way of augmenting fibrinolytic activity in humans, and have proven to be of value in the treatment of acute myocardial infarction and stroke. Although these agents are efficacious in the acute setting, they are not a viable option for long-term use. Net fibrinolytic activity is plasma is largely determined by the balance between tissue-type plasminogen activator (t-PA) and its natural, fast-acting inhibitor, plasminogen activator inhibitor-1 (PAI-1). The recent development of specific PAI-1 antagonists promises to expand the limits of understanding of the role of the fibrinolytic system in human disease, and to break through the current confines of therapeutic options that can effectively restore and augment the activity of the fibrinolytic system.

PMID:
21686234
[PubMed - indexed for MEDLINE]
PMCID:
PMC3116335
Free PMC Article
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