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Int J Mol Sci. 2011;12(5):3006-17. doi: 10.3390/ijms12053006. Epub 2011 May 10.

Optimization of ultrasound-assisted extraction of anthocyanins from mulberry, using response surface methodology.

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  • 1Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; E-Mails: zoutb@163.com (T.-B.Z.); wangmin1605@tom.com (M.W.); ganry_zsu@yahoo.cn (R.-Y.G.).


Mulberry is one of the most widely used traditional Chinese medicines. Anthocyanins are the main bioactive components of mulberry, and possess important biological activities, such as antimicrobial, anti-inflammatory and antioxidant activities. This study investigated the ultrasound-assisted extraction (UAE) of anthocyanins from mulberry by using response surface methodology (RSM). The extraction conditions associated with anthocyanin yield, including extraction solvent, liquid-to-solid rate, temperature and extraction time, are discussed. The optimal conditions obtained by RSM for UAE from mulberry include 63.8% methanol contains 1% (v/v) trifluoroacetic acid (TFA), 43.2 °C temperature, 23.8 (v/w) liquid-to-solid ratio, and 40 min time for the maximum yield (64.70 ± 0.45 mg/g). The results indicated that the UAE can be an effective method for the extraction of some active components from plant materials.


anthocyanins; mulberry; response surface methodology; ultrasound-assisted extraction

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