J Clin Virol. 2011 Oct;52(2):70-8. Epub 2011 Jun 17.

Emerging oseltamivir resistance in seasonal and pandemic influenza A/H1N1.

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Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. crenaud@fhcrc.org

Abstract

The emergence of oseltamivir resistance in seasonal and pandemic influenza A/H1N1 has created challenges for diagnosis and clinical management. This review discusses how clinical virology laboratories have handled diagnosis of oseltamivir-resistant H1N1 and what we have learned from clinical studies and case series. Immunocompetent patients infected with oseltamivir-resistant H1N1 have similar outcomes as patients infected with oseltamivir-susceptible H1N1. However, immunocompromised patients infected with oseltamivir-resistant H1N1 experience potentially more risks of complication and transmissibility with few therapeutic options.

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Emerging oseltamivir resistance in seasonal and pandemic influenza A/H1N1.
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