Cancer Lett. 2011 Oct 1;309(1):46-53. Epub 2011 Jun 17.

Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells.

Ko YC, Chang CL, Chien HF, Wu CH, Lin LI.

Source

Department of Radiological Technology, Yuanpei University, Hsinchu, Taiwan.

Abstract

Resveratrol (3,5,4'-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.

PMID:: 21683516; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Molecular Biology Databases

RESVERATROL - HSDB

Supplemental Content

Save items

Related citations in PubMed

Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. [Blood. 1998]
Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells.
Clément MV, Hirpara JL, Chawdhury SH, Pervaiz S. Blood. 1998 Aug 1; 92(3):996-1002.
Resveratrol induces apoptosis and differentiation in acute promyelocytic leukemia (NB4) cells. [J Asian Nat Prod Res. 2005]
Resveratrol induces apoptosis and differentiation in acute promyelocytic leukemia (NB4) cells.
Cao Y, Wang F, Liu HY, Fu ZD, Han R. J Asian Nat Prod Res. 2005 Aug; 7(4):633-41.
Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions. [Oncogene. 2009]
Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions.
Reis-Sobreiro M, Gajate C, Mollinedo F. Oncogene. 2009 Sep 10; 28(36):3221-34. Epub 2009 Jun 29.
Review Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells. [Invest New Drugs. 2005]
Review Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells.
Atten MJ, Godoy-Romero E, Attar BM, Milson T, Zopel M, Holian O. Invest New Drugs. 2005 Mar; 23(2):111-9.
Review Resveratrol addiction: to die or not to die. [Mol Nutr Food Res. 2009]
Review Resveratrol addiction: to die or not to die.
Shakibaei M, Harikumar KB, Aggarwal BB. Mol Nutr Food Res. 2009 Jan; 53(1):115-28.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Resveratrol enhances the expression of death receptor Fas/CD95 and induces diffe...
Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells.
Cancer Lett. 2011 Oct 1 ;309(1):46-53. Epub 2011 Jun 17 .

PubMed
Do children with blunt head trauma and normal cranial computed tomography scan r...
Do children with blunt head trauma and normal cranial computed tomography scan results require hospitalization for neurologic observation?
Ann Emerg Med. 2011 Oct ;58(4):315-22. Epub 2011 Jun 16 .

PubMed
Specific protein patterns characterize metastatic potential of advanced bladder ...
Specific protein patterns characterize metastatic potential of advanced bladder cancer.
J Urol. 2011 Aug ;186(2):713-20. Epub 2011 Jun 17 .

PubMed
Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high tr...
Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial).
Am J Cardiol. 2011 Sep 1 ;108(5):682-90. Epub 2011 Jun 16 .

PubMed
Invasive pneumococcal disease: association between serotype, clinical presentati...
Invasive pneumococcal disease: association between serotype, clinical presentation and lethality.
Vaccine. 2011 Aug 5 ;29(34):5740-6. Epub 2011 Jun 15 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: