Vaccine. 2011 Aug 5;29(34):5740-6. Epub 2011 Jun 15.

Invasive pneumococcal disease: association between serotype, clinical presentation and lethality.

Rodríguez MA, González AV, Gavín MA, Martínez FM, Marín NG, Blázquez BR, Moreno JC.

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Dirección General de Atención Primaria, Subdirección de Promoción de la Salud y Prevención, Consejería de Sanidad, Comunidad de Madrid, Spain. angeles.gutierrez@salud.madrid.org

Abstract

To ascertain the factors linked to invasive pneumococcal disease (IPD) caused by the different serotypes in the period 2007-2009, following the conjugate vaccine's inclusion in the childhood vaccination schedule, a total of 2013 IPD cases were reviewed. The mean annual incidence in this period was 10.74 cases per 100,000 inhabitans and the lethality was 8.8%. Overall serotype distribution displayed certain peculiarities, such as the high frequency of serotype 5. Serotype 3, male gender, sepsis and presence of risk factors were significantly associated with lethality. Vaccinated children under 5 years of age had a higher risk of disease due to serotype 19A. Serotype 8 was associated with the presence of underlying risk factors.

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